The miR-17-92 MicroRNA Cluster Regulates Multiple
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miRNA The miRNA-17-92 cluster is also predicted to provide important supplementary tools for tumor classification, determination of the treatment plan and analysis of prognosis by clinicians. For example, the use of miR-17 antagonists represents a novel therapeutic approach to the treatment of chronic lymphocytic leukemia . Usually, miRNA clusters consist of two or three miRNAs, but larger clusters also exist, for example, the miR-17-92 cluster is found on human chromosome 13 and is composed of six miRNAs. miRNA clusters play important roles by controlling various cellular processes.
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Mu et al. (2009) analyzed changes in gene expression in a lymphoma cell line derived from a mouse homozygous for the inducible deletion of the miR-17-92 cluster and heterozygous for Em-Myc. They found 568 miR-17-92 cluster in which miR-20 resides. Expression of miR-17-3p and miR-18, additional components of this miRNA cluster, was examined by Northern blot analysis, taking advantage of the fact that miR-17-3p has no homologous miRNA in the human genome and miR-18 has the lowest similarity among the miR-20–related miRNAs. Research work in recent years has revealed unexpected roles of miRNA-17-92 cluster due to its members have function in a wide variety of settings that include normal development, immune diseases, cardiovascular diseases, neurodegenerative diseases and aging. Signosis has developed miR-17-92 cluster real-time PCR kit to detect the expression of 2020-06-17 2013-11-11 · MiR-17/92 is one of the best-known miRNA clusters.
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TGF-B signaling in Neuroblastoma and Renal - AVHANDLINGAR.SE
Proper miR-17~92 cluster is necessary for normal lung development and alterations in expression are reported in other pulmonary diseases. The overall hypothesis for our work is that altered miRNA expression profiles were significantly different between malignant and benign tissue and between cancer subgroups according to ER− status, grade and molecular subtype. miRNAs in the miR-17-92 cluster and miR-17 family were overexpressed in high grade and triple-negative tumors associated with aggressive behavior. Usually, miRNA clusters consist of two or three miRNAs, but larger clusters also exist, for example, the miR-17-92 cluster is found on human chromosome 13 and is composed of six miRNAs. miRNA
In this study, we show that the miR-17-92 cluster is highly expressed in human hepatocellular carcinoma (HCC) tissues compared to the non-tumorous liver tissues by RT-PCR and in situ hybridization analyses.
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By using a lucif- MicroRNA-17-92 cluster mediates the proliferation and survival of neural progenitor cells after stroke. J Biol Chem. 2013; 288:12478–12488. doi: 10.1074/jbc.M112.449025.
25049327 + 373863 DND microRNA-mediated repres. 5.
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Mikrorna-17-92-klustret främjar proliferationen och - byvdev.com
miRNA clusters play important roles by controlling various cellular processes. 2018-10-01 The miR-17-92 cluster is also crucial in the development of B-NHL.