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Pleiotropic effects mediated by inhibition of isoprenoids correlate with the inhibition of cholesterol biosynthesis and are difficult to quantitate. Regulatory agencies require that new cholesterol-lowering treatments should be tested on top of background standard of care therapy, including statins. The most important positive effects of statins are anti-inflammatory, anti-proliferative, antioxidant, immunomodulatory, neuroprotective, anti-diabetes, and antithrombotic, improving endothelial dysfunction and attenuating vascular remodeling besides many others which are discussed under the scope of this review. The rationale is that because many genes now appear to have pleiotropic effects, the drugs that interact with the products of these genes could have uses in multiple body systems. A pharmaceutical company called Pharnext has developed a treatment for a rare, incurable neurodegenerative condition called Charcot-Marie-Tooth disease, which is caused by a single-gene duplication.
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Siegel, G, et al., Inhibition of arteriosclerotic plaque development by 1909 Pleiotropic effects of coat colour-associated mutations in humans, mice and other mammals - Reissmann, Ludwig, 2013 Rabbits – their domestication Mutation in a pleiotropic gene may have an effect on several traits simultaneously, due to the gene coding for a product used by a myriad of cells or different targets that have the same signaling function. Statins have pleiotropic effects-that is, they are simultaneously capable of producing more than one benefit, and in cardiovascular risk reduction, they accomplish more than simply lowering cholesterol. Statin pleiotropy is an important concept. In cell culture and animal studies, these effects alter the expression of endothelial nitric oxide synthase, the stability of atherosclerotic plaques, the production of proinflammatory cytokines and reactive oxygen species, the reactivity of platelets, and the development of cardiac hypertrophy and fibrosis. Pleiotropic effects mediated by inhibition of isoprenoids correlate with the inhibition of cholesterol biosynthesis and are difficult to quantitate.
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Check Answer. Feb 18, 2016 Many genes have multiple phenotypic effects, a property called pleiotropy.
pleiotropic - Swedish translation – Linguee
Statins may also forestall development of the inflammatory disease rheumatoid arthritis. The The Lungs, The Eyes, and More. Statins are are also Se hela listan på academic.oup.com Pleiotropic effects of HIF-1 blockade on tumor radiosensitivity. Moeller BJ(1), Dreher MR, Rabbani ZN, Schroeder T, Cao Y, Li CY, Dewhirst MW. Author information: (1)Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA. Comment in Cancer Cell. 2005 Aug;8(2):89-91. Cancer Cell.
Pleiotropic effects of modified citrus pectin. 2. Galectin-3.
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pleiotropy [pli-ot´rŏ-pe] the production by a single gene of multiple phenotypic effects. The term is often used to refer to a single gene defect that is expressed as
2019-09-24 · Although effects are pleiotropic and affect many cell cycle regulators, the main Cyclin-CDK complexes driving progression through G2 phase show differential regulation in CHH cells.
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Statins are are also Se hela listan på academic.oup.com Pleiotropic effects of HIF-1 blockade on tumor radiosensitivity.